Centre for Clinical Molecular Biology - Aalborg Hospital: Entry ABO

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Gene	Protein	Function	Impact
ABO	Transferase A (alpha 1-3-N-acetyl-galactosaminyl-transferase) Transferase B (alpha 1-3-galactosyl-transferase)	Specific glycosyl-transferring enzymes. Produce the Histo-blood group ABO blood system types. Convert the H antigen to the carbohydrate antigens A or B respectively. O individuals lack such activity	ABO incompatible transfusion may result in death of patients.
ABO:			ABO BLOOD GROUP:

Gene

Protein

Function

Impact

ABO

Transferase A (alpha 1-3-N-acetyl-galactosaminyl-transferase)

Transferase B (alpha 1-3-galactosyl-transferase)

Specific glycosyl-transferring enzymes.

Produce the Histo-blood group ABO blood system types.

Convert the H antigen to the carbohydrate antigens A or B respectively.

O individuals lack such activity

ABO incompatible transfusion may result in death of patients.

ABO:

ABO BLOOD GROUP:

Analyses:
Research only. The ABO genotyping status are investigated utilizing sequencing and a PCR-RFLP method.

Reference on methods:
Grunnet et al., 1994 and Yamamoto F, Clausen H, White T, Marken J, Hakomori S. Molecular genetic basis of the histo-blood group ABO system.
Nature 1990 May 17;345(6272):229-33.

More information about the ABO Blood group system is available at the Blood Group Antigen Gene Mutation Database

Publications:
Bennett EP, Steffensen R, Clausen H, Weghuis DO, van Kessel AG.
Biochem Genomic cloning of the human histo-blood group ABO locus.
Biophys Res Commun 1995 Jan 5;206(1):318-25.

Grunnet N, Steffensen R, Bennett EP, Clausen H.
Evaluation of histo-blood group ABO genotyping in a Danish population: frequency of a novel O allele defined as O2.
Vox Sang 1994;67(2):210-5.

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